Mapping Haplotype-haplotype Interactions with Adaptive LASSO
نویسندگان
چکیده
منابع مشابه
Detecting rare haplotype-environment interaction with logistic Bayesian LASSO.
Two important contributors to missing heritability are believed to be rare variants and gene-environment interaction (GXE). Thus, detecting GXE where G is a rare haplotype variant (rHTV) is a pressing problem. Haplotype analysis is usually the natural second step to follow up on a genomic region that is implicated to be associated through single nucleotide variants (SNV) analysis. Further, rHTV...
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Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. In this article, we describe a statistical model for testing haplotype-haplotype interactions for human diseases with a case-control genetic ass...
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OBJECTIVE Genetic association studies based on haplotypes are powerful in the discovery and characterization of the genetic basis of complex human diseases. However, statistical methods for detecting haplotype-haplotype and haplotype-environment interactions have not yet been fully developed owing to the difficulties encountered: large numbers of potential haplotypes and unknown haplotype pairs...
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The systematic analysis of polymorphisms across large parts of the human genome has begun to provide the first information on haplotypes and the problem of linkage disequilibrium across large genomic regions. These data suggest that significant regions of the genome show highly conserved haplotypes, potentially enhancing the ability to detect disease associations.
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Despite the success achieved in identifying mutations causing Mendelian forms of epilepsy, little progress has been made in illuminating variation contributing to the development of more common forms of the condition. The aim of this thesis was to improve methodology that would aid the detection of variation functional in the development and treatment of common forms of epilepsy. Attempted repl...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2010
ISSN: 1471-2156
DOI: 10.1186/1471-2156-11-79